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・ Discovery (music video)
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・ Discovery and development of ACE inhibitors
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Discovery and development of beta-blockers
・ Discovery and development of beta2 agonists
・ Discovery and development of cephalosporins
・ Discovery and development of cyclooxygenase 2 inhibitors
・ Discovery and development of direct thrombin inhibitors
・ Discovery and development of gliflozins
・ Discovery and development of HIV-protease inhibitors
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・ Discovery and development of matrix metalloproteinase inhibitors
・ Discovery and development of memantine and related compounds
・ Discovery and development of neuraminidase inhibitors
・ Discovery and development of non-nucleoside reverse-transcriptase inhibitors
・ Discovery and development of nucleoside and nucleotide reverse-transcriptase inhibitors
・ Discovery and development of phosphodiesterase 5 inhibitors
・ Discovery and development of proton pump inhibitors


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Discovery and development of beta-blockers : ウィキペディア英語版
Discovery and development of beta-blockers

β-adrenergic receptor antagonists (beta-blockers/β-blockers) were initially developed in the 1960s, for the treatment of angina pectoris but are now also used for hypertension, congestive heart failure and certain arrhythmias. In the 1950s, dichloroisoproterenol (DCI) was discovered to be a β-antagonist that blocked the effects of sympathomimetic amines on bronchodilation, uterine relaxation and heart stimulation. Although DCI had no clinical utility, a change in the compound did provide a clinical candidate, pronethalol, which was introduced in 1962.
== Development ==


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